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Cerebrospinal fluid proteins in subclinical and overt hypothyroidism
Author(s) -
Nyström E.,
Hamberger A.,
Lindstedt G.,
Lundquist C.,
Wikkelsö C.
Publication year - 1997
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1997.tb00216.x
Subject(s) - subclinical infection , cerebrospinal fluid , medicine , endocrinology , thyroid , albumin
Patients and methods ‐ We analysed cerebrospinal fluid (CSF) albumin and immunoglobulin0 G (IgG) concentrations and psychometric performance in subclinical ( n =6) and overt hypothyroidism ( n = 9) before and after 6 months with L‐thyroxine. Results ‐ In overt hypothyroidism, CSF albumin and IgG concentrations were increased before therapy [mean(SD): 328(156) mg/1 and 69(27) mg/1], but within the reference interval [198(48) mg/1 and 39(11) mg/1], P <0.05, after therapy. In contrast, in subclinical hypothyroidism CSF protein concentrations were within the reference intervals before and after therapy. Psychometric testing indicated an improvement in performance in both groups. Conclusion ‐ The increase in CSF proteins in overt hypothyroidism does not appear to be related to thyroid autoimmune disease per se , since we found no increase in CSF proteins in individuals with subclinical hypothyroidism and presence of thyroid antibodies. The increase might rather be caused by a blood‐brain barrier dysfunction related to low thyroid hormone concentrations.