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A quantitative study of daytime sleepiness induced by carbamazepine and add‐on vigabatrin in epileptic patients
Author(s) -
Bonanni E.,
Massetani R.,
Galli R.,
Gneri C.,
Petri M.,
Iudice A.,
Murri L.
Publication year - 1997
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1997.tb00097.x
Subject(s) - multiple sleep latency test , vigabatrin , carbamazepine , excessive daytime sleepiness , epilepsy , anesthesia , medicine , daytime , anticonvulsant , psychology , insomnia , sleep disorder , psychiatry , atmospheric sciences , geology
– The clinical relevance of daytime sleepiness associated with carbamazepine (CBZ) and vigabatrin (VGB) was objectively assessed by the multiple sleep latency test (MSLT) and nocturnal sleep recordings. Material and methods – Twenty‐six patients with partial epilepsy and mean monthly seizure frequency of 4, aged 18 to 48 years, receiving chronic monotherapy with CBZ and subsequent VGB addition for 2 months (14 patients), were compared with a group of healthy subjects. Subjective daytime sleepiness was complained by 13 patients on CBZ monotherapy and 9 patients during VGB add‐on treatment. Results – No differences in nocturnal sleep parameters, but significantly shorter daytime sleep latencies at the MSLT, were detected in CBZ‐treated patients as compared with healthy controls. Addition of VGB therapy did not further enhance objective daytime sleepiness. Conclusion – Some sleepiness occurs in chronically CBZ‐treated epileptic patients, which can be objectively measured by the MSLT, but it is not aggravated by add‐on VGB.