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Amino acid concentrations in cerebrospinal fluid of patients with multiple sclerosis
Author(s) -
Klivényi P.,
Kékesi K.,
Juhász G.,
Vécsei L.
Publication year - 1997
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1997.tb00076.x
Subject(s) - cerebrospinal fluid , multiple sclerosis , amino acid , glutamate receptor , excitatory amino acid transporter , serine , chemistry , medicine , biochemistry , immunology , receptor , enzyme
As oligodendrocytes have binding sites for excitatory amino acids (glutamate, aspartate, serine, etc.), a role of these molecules in demyelinating disorders is possible. We measured the levels of amino acids in the cerebrospinal fluid (CSF) of patients with multiple sclerosis in comparison with CSF obtained by myelography from patients with lower back pain. There were no significant differences in the CSF concentrations of these amino acids between the two groups. Normal concentrations of excitotoxins do not exclude the role of these molecules in demyelinating disorders.