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Correlation between cerebral blood flow values obtained by Xenon/CT and Kety‐Schmidt (N 2 O) methods
Author(s) -
Tone Osamu,
Ito Umeo,
Tomita Hiroki,
Aklmoto Hideaki,
Sakeml Hlsaakl
Publication year - 1996
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1996.tb00535.x
Subject(s) - chemistry , xenon , cerebral blood flow , nuclear medicine , analytical chemistry (journal) , nuclear magnetic resonance , chromatography , medicine , physics , organic chemistry
The means of the cerebral blood flow (CBF) values obtained by the stable xenon enhanced CT (Xe/CT) method using two different CT scanners were compared with the global CBF value obtained by the Kety‐Schmidt (N 2 O) method as a reference. Xe/CT CBF values were obtained using a GE CT9200 (31 patients, 2 flow maps, 120 kV, absorption constant of 0.040) as well as a GE ProSeed Accell (38 patients, 4 flow maps, 80 kV, absorption constant of 0.028). The protocol of inhalation in the Xe/XT method consisted of 4 min wash‐in and 4‐min wash‐out of 35% stable xenon. In the Kety‐Schmidt method, 15% N 2 O gas was inhaled for 10 min. The N 2 O content of blood samples was measured using a van Slyke‐Neill blood gas analyzer. We corrected all obtained CBF values for a PaCO 2 of 34 mmHg (CBF 34 ). The global CBF 34 values obtained by the Kety‐Schmidt method were linearly correlated with the CBF 34 values obtained using the CT9200 and with those obtained using the ProSeed Accell, and the regression line equations were, respectively, Y=0.64X+13.7 (X: CT9200, Y: Kety‐Schmidt, r=0.666, p< 0.01) and Y=0.99X+11.2 (X: ProSeed Accell, Y: Kety‐Schmidt, r= 0.756, p< 0.01). Since the CBF values obtained by the Xe/CT method using different CT scanners are not always the same as the global CBF values obtained by the Kety‐Schmidt method, CBF values obtained by the Xe/CT method should be corrected referring to the regression line obtained by applying both methods for each patient.