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Multimodal evoked potentials in HIV‐1‐seropositive patients: relationship between the immune impairment and the neurophysiological function
Author(s) -
Pierelli F.,
Garrubba C.,
Tilia G.,
Parisi L.,
Fattapposta F.,
Pozzessere G.,
Soldati G.,
Stanzione P.,
D'Offizi G.,
Mezzaroma I.
Publication year - 1996
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1996.tb00519.x
Subject(s) - subclinical infection , encephalopathy , nerve conduction , immunopathology , psychology , central nervous system disease , immune system , human immunodeficiency virus (hiv) , medicine , neuroscience , immunology
Multimodal evoked potentials (PRVEP, BAEP, mSEP) were recorded in 56 HIV‐1 seropositive outpatients free from opportunistic CNS pathologies and/or overt HIV‐1 encephalopathy. EPs were altered in 17 of 39 (43.6%) seropositive subjects without AIDS (group A) and in 13 of 17 (76.5%) patients with AIDS (group B). A high incidence of subclinical alterations (30.8%) were found in group A patients. Significant BAEP (I‐III, III V, I‐V) interpeak latency and mSEP (N9‐N13, N9‐N20) conduction time prolongations were found in group A and B patients. PRVEP PI00 was significantly prolonged only in group B. An inverse relationship between BAEP interpeak latencies and CD4 count was found. Our findings support the hypothesis of an important role of immunodepression in the development of neurophysiologic abnormalities, together with a preferential involvement of acoustic pathways, in the course of HIV‐1 infection.