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Effects of ethanol administration on brain neurotensin‐like immunoreactivity in rats
Author(s) -
Wachi M.,
Fujimaki M.,
Nakamura H.,
Inazuki G.
Publication year - 1996
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1996.tb00202.x
Subject(s) - neurotensin , ethanol , putamen , midbrain , medicine , dopaminergic , endocrinology , chemistry , caudate nucleus , striatum , neuropeptide , anesthesia , dopamine , central nervous system , biochemistry , receptor
The effects of acute and chronic ethanol administration on neurotensin‐like immunoreactivity (NTLI) were investigated in discrete regions of the rat brain. Rats were administered a single dose (5 g/kg) of ethanol or rendered ethanol‐dependent by repeated forced drinking of a 20 % ethanol solution (6–15 g/kg) for 4 days and tested while still intoxicated or at 12–19 h (W‐1) or 7 days (W‐2) after ethanol withdrawal. Increases in NTLI were seen in the caudate‐putamen in the toxic, W‐1 and W‐2 groups and decreases were observed in the midbrain in the toxic and W‐1 groups. It was assumed that ethanol produced the changes of NTLI in the caudate‐putamen and midbrain through its actions upon the dopaminergic system.