Premium
V region T cell receptor repertoire in Parkinson's disease
Author(s) -
Fiszer U.,
Fredrikson S.,
Mix E.,
Olsson T.,
Link H.
Publication year - 1996
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1996.tb00165.x
Subject(s) - t cell receptor , cd8 , pathogenesis , biology , immunology , beta (programming language) , t cell , cytotoxic t cell , t lymphocyte , repertoire , receptor , antigen , genetics , immune system , computer science , acoustics , in vitro , programming language , physics
‐ Restricted usage of Vα and β genes has been found in several diseases, which exert autoreactive T cells. So far no information on T cell receptor (TCR) usage in degenerative diseases is available. Since T cells may be involved in pathogenesis of Parkinson's disease, the analysis of the TCR repertoire is of importance. Material and methods ‐ We have tested the frequency of 6 Vβ‐subtypes and the most common Vα‐subfamily on peripheral blood lymphocytes in 21 PD patients and 20 controls, separately on CD4 + and CD8 + T cells. For our study Diversi ‐ T™, the first available Mab set specific for TCR V regions, was used. Results ‐As a results, no significant differences were found with one exception, i.e., lower frequency of Vβ8(a) expression on CD8 + T cells in PD patients than in controls. Conclusion ‐ The failure of preferential usage or lack of usage of the tested V‐chain alleles by CD4 + T cells argues against an involvement of helper T cells in PD induction.