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Autosomal recessive paraparesis with amyotrophy of hands and feet and white matter lesions
Author(s) -
Malandrini A.,
Scarpini C.,
Villanova M.,
Sicurelli F.,
Parrotta E.,
DeFalco D.,
Guazzi GC.
Publication year - 1996
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1996.tb00040.x
Subject(s) - amyotrophy , medicine , white matter , spastic , anatomy , pathology , atrophy , physical medicine and rehabilitation , magnetic resonance imaging , radiology , cerebral palsy
We report two siblings with a hitherto undescribed syndrome of autosomal recessive spastic paraparesis accompanied by amyotrophy of hands and feet, and mental deterioration. Laboratory tests showed signs of lower motoneuron involvement in the four limbs, more accentuated in the distal regions. Brain MR showed bilateral symmetrical white matter lesions. We discuss the nosological status of this syndrome in relation to other similar forms of “complicated” spastic paraparesis.