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Increased CSF C4d in demyelinating neuropathy indicates the radicular involvement
Author(s) -
Koguchi Y.,
Yamada T.,
Kuwabara S.,
Nakajima M.,
Hirayama K.
Publication year - 1995
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1995.tb05844.x
Subject(s) - cerebrospinal fluid , medicine , chronic inflammatory demyelinating polyneuropathy , polyneuropathy , guillain barre syndrome , demyelinating disorder , pathology , gastroenterology , immunology , central nervous system , antibody
Plasma and cerebrospinal fluid (CSF) levels of C4d and the circulating immune complex (CIC) to Clq were measured in 12 patients with chronic inflammatory demyelinating polyneuropathy and Guillain‐Barré syndrome. CSF C4d values more than 2 SD from the mean of 8 cervical spongylosis cases were demonstrated in the patients with proximal demyelination. The CSF C4d probably originated from both intrathecal synthesis and the systemic circulation. CSF levels of C4d may serve as a sensitive indicator for the radicular involvement in demyelinating polyneuropathy.