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Prevention of neuronal cell death by anticonvulsants in experimental epilepsy (extended abstract)
Author(s) -
Pitkanen A.,
Halonen T.
Publication year - 1995
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1995.tb00494.x
Subject(s) - epilepsy , temporal lobe , hippocampus , neuroscience , entorhinal cortex , premovement neuronal activity , psychology , medicine
In human temporal lobe epilepsy, neuronal cell damage is found in the hippocampus (1) as well as in the amygdaloid complex (2) and entorhin‐al cortex (3). Data from animal studies show that recurrent seizures selectively injure certain populations of neurons in the temporal lobe structures (4). Whether or not recurrent seizures cause neuronal damage in human epilepsy is still under investigation. A new challenge for anti‐epilepsy medication is not only to suppress clinical seizures but also to prevent any neuronal damage caused by the seizures.