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Anticardiolipin antibodies in acute non‐hemorrhagic stroke seen within six hours after onset
Author(s) -
Camerlingo M.,
Casto L.,
Censori B.,
Drago G.,
Frigeni A.,
Ferraro B.,
Servalli M. C.,
Radice E.,
Mamoli A.
Publication year - 1995
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1995.tb00469.x
Subject(s) - medicine , stroke (engine) , anticardiolipin antibodies , antibody , risk factor , logistic regression , atrial fibrillation , isotype , prospective cohort study , gastroenterology , cardiology , immunology , thrombosis , monoclonal antibody , mechanical engineering , engineering
– We have undertaken a prospective study to measure anticardiolipin antibodies of IgG isotype within the first few hours of an acute non‐hemorrhagic stroke. Material and methods – We have collected blood samples at entry from one hundred patients (53 men and 47 women), mean age 67.4 years, referred within 6 h of a first‐ever non‐hemorrhagic stroke, and from an equal number of age‐ and gender‐matched control patients. Results – IgG anticardiolipin antibodies were 10 GPL in 26 patients and in 5 controls (p <0.0001, X2 test). After logistic regression analysis, increase of IgG anticardiolipin antibodies remained independently associated with stroke (p = 0.0034), together with hypertension (p = 0.0009) and atrial fibrillation (p = 0.0238). Conclusion – Our data suggest that the occurrence of elevation of IgG anticardiolipin antibodies in stroke patients should antedate stroke onset and might be a risk factor per se .