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Hypersensitivity of cortical muscarinic receptors in Parkinson's disease demonstrated by PET
Author(s) -
Asahina M.,
Shinotoh H.,
Hirayama K.,
Suhara T.,
Shishido F.,
Inoue O.,
Tateno Y.
Publication year - 1995
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1995.tb00443.x
Subject(s) - muscarinic acetylcholine receptor , frontal lobe , positron emission tomography , medicine , temporal cortex , cortex (anatomy) , cholinergic , neuroscience , parkinson's disease , wisconsin card sorting test , psychology , nuclear medicine , receptor , disease , cognition , neuropsychology
The status of muscarinic receptors (mAChRs) is not clear in Parkinson's disease (PD). We measured mAChR binding in the brain of eight patients with PD and eight, age‐matched, healthy controls by positron emission tomography (PET) and [ 11 C]N‐methyl‐4‐piperidyl benzilate ([ 11 C]NMPB). PD patients were not demented according to DSM III criteria but showed significant frontal lobe dysfunction in the Modified Wisconsin Card Sorting Test. A mean K 3 value, which is an index of mAChR binding calculated by a graphical method, was 20% higher in the frontal cortex of PD patients than controls (p<0.05). Hypersensitivity of mAChRs in the frontal cortex of PD patients may be a response to a loss of ascending cholinergic input to that region, and may relate to frontal lobe dysfunction in PD.