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T cell subsets in multiple sclerosis: a serial study
Author(s) -
Calopa M.,
Bas J.,
Mestre M.,
Arbizu T.,
Peres J.,
Buendia E.
Publication year - 1995
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1995.tb00147.x
Subject(s) - multiple sclerosis , cd19 , cd8 , immune system , immunology , medicine , il 2 receptor , clinical significance , flow cytometry , peripheral blood lymphocyte , lymphocyte , lymphocyte subsets , t cell
The relevance of abnormalities in the distribution of peripheral blood T lymphocyte subsets to the clinical manifestations of multiple sclerosis is not firmly established. A clinical and immunological follow‐up of relapsing‐remitting multiple sclerosis patients was performed in order to study the relationship of immune changes with the clinical course of the disease. Twenty patients were monitored monthly during a mean time of nine months for peripheral blood lymphocyte subsets (CD3, CD4, CD8, CD19), including the immunoregulatory subsets CD4CD29 (helper‐inducer), and CD4CD45RA (suppressor‐inducer) and activated T helper cells (CD4CD25) by flow cytometry. A total of 14 untreated relapses was included. The most significant observations were a decrease in T suppressor‐inducer CD4 + CD45RA + subset during clinical relapses ( P = 0.028) that was also detectable one month before ( P = 0.020) and the lack of changes in CD4 + CD29 + and CD8 + T cells. In addition, variations in the percentage of CD4 + CD25 + activated T helper cells were not associated with clinical exacerbations. These results indicate the existence of a temporal association of immune changes in peripheral blood, but not activation, with the clinical manifestations of multiple sclerosis.