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Materials and Methods
Author(s) -
B. Nasraoui,
M. Ben-Hammouda,
M. Boubaker,
O. Ben-Salem,
Y. Shibayama
Publication year - 1994
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1994.tb08114.x
Subject(s) - citation , information retrieval , computer science , library science , world wide web
Table 1 summarizes the patients and controls examined for cytokine mRNA expression in MNC without culture of the cells. Table 2 shows the materials analyzed for cytokine mRNA positive MNC after culture in presence and absence of antigen. In Table 3, the patient groups are defined from whom CSF and blood were obtained in parallel for the study of cytokine mRNA expression in MNC. Multiple sclerosis. The patients with MS fullfilled the criteria of clinically definite MS (182). Exacerbation is defined as a sudden appearance of new symptoms and signs or the abrupt reappearance or worsening of previously present signs and symptoms lasting >24 h and occurring within 1 month before examination. Patients with no or slight disability were in all respects able to manage on their own, while those with moderate or severe disability were dependent on assistance for their professional and social lifes. In one study (I), the MS patients were subdivided according to the expanded disability status scale (EDSS) (183) into those with no or slight disability equal to an EDSS score <3, and those with more severe disability defined as an EDSS score a3. Optic neuritis. This group consisted of patients with acute unilateral ON, diagnosed as described (28). Myasthenia gmvis. The diagnosis of MG was based on the presence of characteristic clinical signs and symptoms, the results from laboratory