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H magnetic resonance spectroscopy in the investigation of intractable epilepsy
Author(s) -
Gadian D. G.,
Connelly A.,
Duncan J. S.,
Cross J. H.,
Kirkham F. J.,
Johnson C. L.,
VarghaKhadem F.,
Nevile B. G. R.,
Jackson G. D.,
Gadian David
Publication year - 1994
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1994.tb05202.x
Subject(s) - creatine , phosphocreatine , epilepsy , nuclear magnetic resonance , choline , chemistry , nuclear magnetic resonance spectroscopy , proton magnetic resonance , spectroscopy , phosphomonoesters , magnetic resonance imaging , medicine , neuroscience , psychology , biochemistry , physics , quantum mechanics , radiology , energy metabolism
We have been using proton magnetic resonance spectroscopy ( 1 H MRS) in the investigation of adults and children with intractable epilepsy. Spectra were obtained from 2 × 2 times 2 cm cubes in the medial region of the temporal lobe, and were analyzed on the basis of signals from N‐acetylaspartate (NAA), creatine+phosphocreatine (Cr), and choline‐containing compounds (Cho). In comparison with control subjects, the epilepsy patients as a group show significant reductions in the NAA signal and in the NAA/Cho + Cr ratio, with increases in the Cho and Cr signals. The reduction in NAA is interpreted in terms of neuronal loss or damage, while the increase in Cr and Cho signals may be a reflection of reactive astrocytosis.