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Optic neuritis and multiple sclerosis: the T cell repertoires to myelin proteins and MBP peptides change with time
Author(s) -
Söderström M.,
Link H.,
Fredrikson S.,
Sun J.B.
Publication year - 1994
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1994.tb02673.x
Subject(s) - multiple sclerosis , myelin basic protein , optic neuritis , myelin , immunology , proteolipid protein 1 , antigen , myelin proteolipid protein , t cell , medicine , biology , immune system , central nervous system
Autoreactive T cells recognizing myelin basic protein (MBP), proteolipid protein (PLP) and MBP peptides have been described in multiple sclerosis (MS) and optic neuritis (ON), but their role in disease pathogenesis, if any, is unknown. A consistency of the T cell repertoire over the course of MS and ON should facilitate the development of specific immunotherapies. We have examined the T cell responses to autoantigens in two consecutive blood specimens taken from patients with ON and MS, and in two consecutive CSF specimens obtained from ON patients. As read‐out numbers of T cells responding to antigen stimulation by the secretion of interferon‐γ were estimated. Pronounced differences in occurrence and numbers of T cells recognizing MBP, MBP peptides with the amino acid sequences 63–88, 110–128 and 148–165, and PLP were noticed in individual ON and MS patients over the course of disease. The MBP peptide among those three included, that was predominantly recognized by T cells in the individual patient, also varied over the course. The quantitative and qualitative changes of the myelin antigen‐specific T cell response in MS and in ON, the latter to a certain extent reflecting the situation in early MS, do not favor the future useful development of specific immunotherapies in these diseases.