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Effect of pancreas and kidney transplantation on the neuropathic profile in insulin‐dependent diabetics with end‐stage nephropathy
Author(s) -
Trojaborg W.,
Smith T.,
Jakobsen J.,
Rasmussen K.
Publication year - 1994
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1994.tb02672.x
Subject(s) - medicine , diabetes mellitus , pancreas transplantation , transplantation , diabetic nephropathy , pancreas , kidney , urology , kidney transplantation , surgery , endocrinology
From a series of 26 diabetics selected for combined pancreas and kidney transplantations 9 died before surgery was scheduled, one died after surgery and 4 rejected the transplants. The effect of pancreas or kidney transplantation or both on vibratory perception and thermal thresholds, various motor and sensory conduction parameters were studied in 9 of the remaining 12 patients. In 6 both the pancreatic and renal grafts were functioning, in 2 the pancreas was rejected, and in 1 the kidney. At an average follow‐up of 41 months after surgery, the mean total score of clinical and electrophysiological improvement in 6 patients with successful combined transplantation was 5.5±1.6 compared with – 4.3±2.5 in 3 patients with one surviving transplant (P<0.001). Similarly, the average increase in nerve conduction velocity was 5.8±1.1 m/s in patients with two functioning grafts whereas it decreased 2.9±0.7 m/s in those with only one (P<0.001). The quality of life was considered improved in patients with successful outcome of the two organ transplantations in contrast to the statements of those with only one.