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Autoantibodies to myelin basic protein are not present in the serum and CSF of MS patients
Author(s) -
Brokstad K. A.,
Page M.,
Nyland H.,
Haaheim L.R.
Publication year - 1994
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1994.tb02657.x
Subject(s) - myelin basic protein , autoantibody , western blot , multiple sclerosis , cerebrospinal fluid , myelin , antibody , immunoassay , immunology , medicine , pathology , biology , central nervous system , biochemistry , gene
Myelin basic protein (MBP) is one of the main constituents of the CNS myelin sheaths, and an autoimmune response directed against MBP may be crucial in the demyelination process in patients with multiple sclerosis (MS). In this study sera and cerebrospinal fluid (CSF) from 25 MS patients, 25 patients with other neurological diseases and 16 healthy controls were examined for antibodies against MBP by using radio immunoblot, western blot, radio immunoassay and enzyme‐linked immunosorbant assay. No evidence for the presence of antibodies to MBP was found in sera or CSFs in either the MS patients, or in the control groups tested.