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Single photon emission computed tomography with [ 99 Tc]‐HM‐PAO and [ 123 I]‐IBZM in Alzheimer's disease and dementia of frontal type: preliminary results
Author(s) -
Frisoni G.B.,
Pizzolato G.,
Bianchetti A.,
Chierichetti F.,
Ferlin G.,
Battistin L.,
Trabucchi M.
Publication year - 1994
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1994.tb01661.x
Subject(s) - dementia , single photon emission computed tomography , alzheimer's disease , medicine , positron emission tomography , emission computed tomography , computed tomography , disease , nuclear medicine , psychology , pathology , radiology
Dementia of frontal type (DFT) is a fairly common degenerative disease distinct from Alzheimer's disease (AD), whose reportedly distinctive instrumental feature is frontal lobe hypoperfusion on SPECT. We evaluated the cortical dopaminergic system in 6 AD, 5 DFT, and 6 control subjects with SPECT and both [ 99 Tc]‐HM‐PAO, a perfusion tracer, and [ 123 I]‐IBZM, a D2 postsynaptic ligand. Both in AD and DFT patients, [ 99 Tc]‐HM‐PAO SPECT showed a relative frontal hypoperfusion. On the contrary, [ 123 I]‐IBZM SPECT showed significantly reduced ligand uptake in superior frontal regions of DFT (0.89 ± 0.08 relative to control subjects) as compared to AD patients (0.97 ± 0.02; difference of means: 0.08, 95% Confidence Interval 0.004 to 0.156; p = 0.041). Results suggest more marked involvement of the frontal cortical dopaminergic system in DFT than in AD patients.