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Arylsulphatase A (ASA) activity in parkinsonism and symptomatic essential tremor
Author(s) -
Martinelli P.,
Ippoliti M.,
Montanari M.,
Martinelli A.,
Mochi M.,
Giuliani S.,
Sangiorgi S.
Publication year - 1994
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1994.tb01656.x
Subject(s) - parkinsonism , essential tremor , medicine , parkinson's disease , movement disorders , disease , pediatrics , physical medicine and rehabilitation
Arylsulphatase A (ASA) activity was evaluated in 47 patients with a diagnosis of parkinsonism or essential tremor. Mean ASA activity was significantly reduced compared with both a healthy control group of 71 individuals (p < 0.01) and with a group of 44 neurological patients without movement disorders (p < 0.02). Using definite clinical criteria the patients were classified as typical or atypical with respect to Parkinson's disease (PD) or essential tremor (ET). A normal ASA level was found in all the cases showing typical clinical features (PD and ET), while ASA activity was significantly lowered (p < 0.01) in 55.6% of the atypical cases (Parkinsonian syndrome or symptomatic ET). Our data support the hypothesis of a non‐casual association between low ASA level and the clinical features of parkinsonism or symptomatic ET.