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Eye movement quantitative evaluation before and after high‐dose 6‐methylprednisolone in multiple sclerosis
Author(s) -
Versino M.,
Bergamaschi R.,
Callieco R.,
Romani A.,
Castelnovo G.,
Beltrami G.,
Cosi V.
Publication year - 1994
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1994.tb01644.x
Subject(s) - saccadic masking , saccade , eye movement , smooth pursuit , latency (audio) , abnormality , multiple sclerosis , methylprednisolone , neurophysiology , physical medicine and rehabilitation , audiology , medicine , electrooculography , ophthalmology , anesthesia , psychology , neuroscience , computer science , psychiatry , telecommunications
We studied saccadic and smooth pursuit eye movements in 24 patients suffering from multiple sclerosis during disease worsening, before and after high‐dose 6‐methylprednisolone infusions. Quantitative evaluation of saccades was based on amplitude/duration and amplitude/peak velocity relationships, precision (i.e. the ratio of actual to desired saccade amplitude) and the latency, whereas smooth pursuit eye movements were studied using target velocity/performance index relationship. At basal recordings, 22/24 (91.7%) of the patients showed at lest one abnormality. Eleven of the 24 patients (45.8%) showed modification of one or several parameters: improvement in 6 patients, worsening in 2, coexistence of both trends in 3. Latency improvement was the only significant modification when patients were considered as a group. Neurophysiological modifications did not correspond to clinical changes.