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Effect of high‐dose steroid therapy on T‐cell subpopulations A longitudinal study in MS patients
Author(s) -
Gallo P.,
Chiusole M.,
Sanzari M.,
Sivieri S.,
Piccinno M. G.,
Argentiero V.,
Rizzotti P.,
Tavolato B.
Publication year - 1994
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1994.tb01642.x
Subject(s) - steroid , longitudinal study , medicine , oncology , pathology , hormone
Lymphocyte subpopulations, T cell activation antigens, and serum levels of interleukin 2 (IL‐2) and soluble IL‐2 receptor (sIL2R), were studied in relapsing‐remitting MS (RR‐MS) patients before and after high‐dose steroid therapy. Prior to therapy, a minority of patients showed increased HLA‐DR antigen expression, and an increased number of CD16 + and CD19+ cells. Steroid treatment induced a significant increase in HLA‐DR and CD 19 expression, a significant reduction in CD 16 +, CD57 +, and CD8 + CD57 + cells, and a slight, non‐significant, decrease in IL‐2 and sIL‐2R levels and CD25 expression on CD4 + T lymphocytes.