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Cytokine production by peripheral blood monocytes/macrophages in multiple sclerosis patients
Author(s) -
Imamura K.,
Suzumura A.,
Hayashi F.,
Marunouchi T.
Publication year - 1993
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1993.tb05508.x
Subject(s) - multiple sclerosis , medicine , cytokine , exacerbation , tumor necrosis factor alpha , immunology , lipopolysaccharide , monocyte , peripheral , interleukin 6 , interleukin
To determine the function of monocytes/macrophages in the acute phase of multiple sclerosis (MS), we investigated the production of tumor necrosis factor α (TNFα), interleukin‐1α (IL‐1α), IL‐1β and IL‐6 by peripheral blood monocytes/macrophages (PBM) in patients with MS, other autoimmune neurological disease (OAND), other neurological disease (OND) and normal controls was assessed using enzyme‐linked immunosorbent assay (ELISA). When stimulated with lipopolysaccharide or phorbol ester, PBM obtained during acute phase of MS relapse patients produced significantly higher amounts of all these cytokines than did PBM from patients with chronic stable MS or OAND or OND or from normal controls. The results suggest a possible role of activated monocytes/macrophages in the actue exacerbation of MS.