Premium
Histologic evidence for a toxic polyneuropathy due to exposure to 2,3,7,8 — tetrachlorodibenzo‐p‐dioxin (TCDD) in rats
Author(s) -
Grehl H.,
Grahmann F.,
Claus D.,
Neundörfer B.
Publication year - 1993
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1993.tb05357.x
Subject(s) - neurotoxicity , polyneuropathy , toxicity , corn oil , medicine , tetrachlorodibenzo p dioxin , endocrinology , microgram , toxicology , chemistry , biology , biochemistry , in vitro
2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) is a considerable environmental hazard in industrial societies. Its toxic effects on animals and humans are numerous, but little is known about its neurotoxicity. We studied the neurotoxic effects of TCDD in 80 male, adult Wistar rats. The substance was dissolved in corn oil and a single dose injected intraperitoneally (8.8 μg, 6.6 μg, 4.4μg or 2.2μg/kg). Neurophysiological examinations proved a dose‐related, statistically significant slowing of sensory and motor conduction velocities. Ten months after the application of TCDD peripheral nerves showed a progressive, and proximally accentuated neuropathy. The extent of changes, however, differed remarkably between individual animals. Our data indicate that TCDD caused a toxic polyneuropathy in rats.