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Discrimination of Alzheimer patients responding to cholinesterase inhibitor therapy
Author(s) -
Alhainen K.,
Riekkinen P. J.
Publication year - 1993
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1993.tb04248.x
Subject(s) - tacrine , cholinesterase , neuropsychology , alzheimer's disease , medicine , psychology , electroencephalography , disease , pharmacology , neuroscience , cognition , acetylcholinesterase , chemistry , biochemistry , enzyme
We have studied whether it is possible to discriminate responders to tacrine treatment from patients nonresponsive to tacrine in Alzheimer's disease. The results indicate that mildly demented patients will most likely gain a benefit of tacrine treatment. Neuropsychological tests on attention and working memory after a single dose of tacrine might be useful as well as a single dose pharmaco‐EEG in discriminating responders to treatment.