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Biochemical pathology and treatment strategies in Alzheimer's disease: Emphasis on the cholinergic system
Author(s) -
Winblad B.,
Messamore E.,
O'Neill C.,
Cowburn R.
Publication year - 1993
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1993.tb04244.x
Subject(s) - neurochemical , cholinergic , neuroscience , dementia , alzheimer's disease , tau pathology , disease , cholinergic system , degenerative disease , cholinergic neuron , neurotransmitter , cerebral cortex , neurotransmitter systems , medicine , psychology , pathology , central nervous system disease , central nervous system , dopamine
The neurochemical pathology of Alzheimer's disease (AD) has been consistently shown to involve cholinergic degeneration in the cerebral cortex. This together with evidence from experimental animal studies showing that cholinergic neurones play a role in learning and memory processes has formed the basis of the cholinergic hypothesis of Alzheimer's dementia and the major rationale for neurotransmitter replacement therapy of the disorder.