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GFAP‐specific oligoclonal bands in the CSF of a patient with acute myelitis
Author(s) -
Kaiser R.,
Lücking C. H.
Publication year - 1993
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1993.tb04197.x
Subject(s) - myelitis , glial fibrillary acidic protein , pathology , spinal cord , blot , neuromyelitis optica , astrocyte , isoelectric focusing , immunohistochemistry , medicine , lesion , monoclonal antibody , antibody , immunology , chemistry , central nervous system , biochemistry , psychiatry , gene , enzyme
The specificity for GFAP (glial fibrillary acidic protein) of oligoclonal IgG bands in the CSF of a patient with acute myelitis was demonstrated by isoelectric focusing and affinity blotting. Findings were confirmed by western blotting using a monoclonal antibody to GFAP as a reference. Immune reactions to this astrocyte protein are considered as arising secondary to spinal cord tissue lesion.