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Absence of brain antibodies in the sera of relapsing‐remitting multiple sclerosis patients is not due to the formation of immune complexes
Author(s) -
Henneberg A. E.,
Elsner U.,
Kornhuber H. H.
Publication year - 1993
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1993.tb04135.x
Subject(s) - multiple sclerosis , antibody , relapsing remitting , idiotype , immune system , immunology , medicine , immune complex , monoclonal antibody
Using an enzyme‐linked immunoadsorbent assay, we looked, whether the formation of idiotype‐antiidiotype complexes was responsible for the absence of antibodies in the sera of MS patients. We tested 18 relapsing‐remitting and 26 chronic progressive patients versus 44 age‐ and sex‐matched controls. We did not find elevated titres of immune complexes in the sera of the multiple sclerosis patients.