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Electrophysiological study of neurologically asymptomatic HIV1 seropositive patients
Author(s) -
Ragazzoni A.,
Grippo A.,
Ghidini P.,
Schiavone V.,
Lolli F.,
Mazzotta F.,
Mecocci L.,
Pinto F.
Publication year - 1993
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1993.tb04074.x
Subject(s) - asymptomatic , subclinical infection , electrophysiology , brainstem , medicine , electroencephalography , audiology , asymptomatic carrier , human immunodeficiency virus (hiv) , pediatrics , psychology , psychiatry , immunology
EEGs, brainstem auditory evoked potentials (BAEPs) and auditory event‐related potentials (ERPs) were recorded from 33 individuals infected with the human immunodeficiency virus, type 1 (HIV1 + patients: 13 CDC Class II or III; 20 Class IV). All were neurologically asymptomatic, non‐demented, and had a past history of intravenous drug abuse. Sixteen age‐ and sex‐matched normals and 10 HIV1 ‐ former drug addicts served as controls. Half of the HIV1 + and HIV1 ‐ subjects displayed mild EEG anomalies and, except for one HIV1 + patient, BAEPs were normal in both groups. ERPs were normal in all HIV1 ‐ subjects but anomalous (longer latencies of components P2, N2, P3; reduced amplitude of P3) in 9 HIV1 + patients (27%), the incidence of such anomalies being higher for Class IV than Class II/III patients. Auditory ERPs proved the most sensitive and specific of these electrophysiological procedures in detecting subclinical central nervous system involvement in HIV1 infection.