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Serum anti‐GM 1 and anti‐GD 1a antibodies in patients with motor neuron disease
Author(s) -
Voumvourakis C.,
Rombos A.,
Konstantoulakis M. M.,
Segditsa I.,
Papageorgiou C.
Publication year - 1992
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1992.tb05495.x
Subject(s) - antibody , peripheral neuropathy , medicine , motor neuron , dementia , disease , degenerative disease , immunology , peripheral , multifocal motor neuropathy , gastroenterology , endocrinology , diabetes mellitus , mismatch negativity , electroencephalography , psychiatry
Using an enzyme‐linked immunosorbent assay (ELISA) sera from 100 individuals, 20 with motor neuron disease (MND), 25 with peripheral neuropathy (PN), 15 with degenerative dementia and 40 controls, were examined in order to detect serum IgM and IgG anti‐GM 1 and anti‐GD 1a antibodies. Patients with MND showed statistically significant higher levels of IgM anti‐GM 1 antibody compared to the control group. Three patients with peripheral neuropathy had very high levels of anti‐GM 1 and anti‐GD 1a antibodies. Antibody levels in patients with degenerative dementia showed no difference compared to the controls. These results suggest that a further inquiry into the role of serum anti‐GM 1 and anti‐GD 1a activity in motor neuron disease and peripheral neuropathy is necessary.