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Leukotrienes in the cerebrospinal fluid of multiple sclerosis patients
Author(s) -
Neu I.,
Mallinger J.,
Wildfeuer A.,
Mehlber L.
Publication year - 1992
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1992.tb05491.x
Subject(s) - multiple sclerosis , cerebrospinal fluid , leukotriene c4 , leukotriene , leukotriene b4 , medicine , immunology , inflammation , asthma
The concentration of the leukotrienes B 4 (LTB 4 ) and C 4 (LTC 4 ) was measured in the cerebrospinal fluid (CSF) of 38 multiple sclerosis (MS) patients and 51 with other neurological diseases. The LTB 4 and LTC 4 levels were significantly elevated in MS compared with the controls. The findings suggest that lipoxygenase products might play a pathogenetic role in the early, encephalitogenic phase of MS. The administration of lipoxygenase inhibitors or leukotriene antagonists might well open new perspectives for the treatment of MS.