CSF and serum ganglioside antibody patterns in MS | Zendy

Stevens A. | Zendy; Weller M. | Zendy; Wiethölter H. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

CSF and serum ganglioside antibody patterns in MS

Author(s) -

Stevens A.,

Weller M.,

Wiethölter H.

Publication year - 1992

Publication title -

acta neurologica scandinavica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.967

H-Index - 95

eISSN - 1600-0404

pISSN - 0001-6314

DOI - 10.1111/j.1600-0404.1992.tb05129.x

Subject(s) - ganglioside , multiple sclerosis , antibody , neuroborreliosis , medicine , immunology , guillain barre syndrome , biology , biochemistry , borrelia burgdorferi

The authors determined CSF and serum IgG and IgM antibodies to seven gangliosides in 48 patients with multiple sclerosis. Differing ganglioside antibody patterns in CSF but not serum allowed to reclassify 93% of MS patients correctly when compared to patients with Guillain‐Barré syndrome or neuroborreliosis. This suggest that the antibody patterns are neither random nor alike in inflammatory diseases of the nervous system. CSF ganglioside antibody titres were found to be different for patients with relapsing remitting (RRMS; n = 35) and chronic progressive (CPMS; n = 13) multiple sclerosis. Our study reveals characteristic ganglioside antibody patterns in MS and confirms previous evidence of disturbed immunoregulation in MS.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Empowering knowledge with every search