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Immunosuppression by whole‐body irradiation and its effect on oedema in experimental cerebral ischaemia
Author(s) -
Strachan R. D.,
Kane P. J.,
Cook S.,
Chambers I. R.,
Clayton C. B.,
Mendelow A. D.
Publication year - 1992
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1992.tb05081.x
Subject(s) - immunosuppression , medicine , irradiation , whole body irradiation , ischemia , cerebral edema , occlusion , edema , brain edema , middle cerebral artery , cerebral arteries , anesthesia , transplantation , physics , nuclear physics
The effect of global immunosuppression by sublethal whole body X‐irradiation on the development of cerebral oedema was assessed 24 h after right middle cerebral artery occlusion in the rat. Irradiation produced a significant leucopaenia and thrombocytopaenia, and significantly reduced cortical oedema when compared to non‐irradiated control animals.