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Synthesis of the complement factors C 3 and C 4 within the central nervous system over the course of aseptic meningitis
Author(s) -
Frydén A.,
Forsberg P.,
Link H.
Publication year - 1992
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1992.tb05044.x
Subject(s) - aseptic meningitis , radial immunodiffusion , cerebrospinal fluid , central nervous system , intrathecal , csf albumin , complement system , medicine , meningitis , gastroenterology , immunology , endocrinology , anesthesia , surgery , antibody
The concentrations of complement factors C 3 and C 4 were quantified by single radial immunodiffusion in unconcentrated cerebrospinal fluid (CSF) and in serum from 38 patients up to 2 months after onset of acute aseptic meningitigs (AM). Elevated absolute concentrations were found in CSF in 26 and 35 patients, respectively, and in serum in 8 and 31, respectively. Elevation of the CSF C 3 index, equal to (CSF/serum C 3 ):(CSF/serum albumin), and of the corresponding CSF C 4 index were found in 16 and 7 patients, respectively, as evidence of intrathecal synthesis. Only minor differences of the frequencies of elevated CSF C 3 and C 4 indices were encountered over the course of AM up to 2 months after onset. The occurrence of intrathecal C 3 and C 4 synthesis in AM is proposed as reflecting activation of hitherto unknown significance within the central nervous system.