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Opsoclonus in a patient with Guillain‐Barré syndrome
Author(s) -
Nicolai A.,
Lazzarino L. G.
Publication year - 1992
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1992.tb04061.x
Subject(s) - opsoclonus , guillain barre syndrome , medicine , pathogenesis , immune system , disease , immunology , limiting , neuroscience , pathology , psychology , biology , neuroblastoma , genetics , cell culture , mechanical engineering , engineering
A 54 year‐old woman showed the unusual association of a Guillain‐Barré syndrome and opsoclonus, a rare eye movement characterized by involuntary bursts of jerking, ataxic and multidirectional saccades, without an intersaccadic interval. Since opsoclonus is a phenomenon described exclusively in CNS diseases, the cases reported supports the hypothesis of CNS involvement in some cases of Guillain‐Barré syndrome. The latter is generally considered an immune‐mediated disease and an immune pathogenesis is also supposed in opsoclonus associated with systemic malignancies; besides, in the patient reported, the self‐limiting nature of the disturbance and the lack of MRI lesions suggest that opsoclonus may result from an immune‐related phenomenon causing a functional and transitory dysfunction of the CNS.