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Early prognostic factors for disability in multiple sclerosis, a European multicenter study
Author(s) -
Riise T.,
Grønning M.,
Fernández O.,
Lauer K.,
Midgard R.,
Minderhoud J. M.,
Nyland H.,
Pálffy G.,
Poser S.,
Aarli J. A.
Publication year - 1992
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1992.tb04031.x
Subject(s) - medicine , multiple sclerosis , multicenter study , physical therapy , pediatrics , randomized controlled trial , immunology
The effects of initial clinical variables on short‐term prognosis are analyzed in a cross‐sectional study of 574 multiple sclerosis patients from 7 centers in 5 European countries. Patients with a primary progressive course had a 2.3 higher mean disability score (EDSS) than the primary remittent group after a mean duration of disease of 6.6 years. High age at onset was associated with a primary progressive course, and was also related to increased risk of a rapid shift to a secondary progressive course. Among the remittent patients without a secondary progressive course a high age at onset was significantly correlated to a higher disability score. In the whole remittent group the presence of pyramidal and cerebellar symptoms at onset predicted both a high disability score and a rapid shift to a secondary progression, while the effect was reverse for sensory and visual symptoms. No difference between the sexes was found.