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Monoamine oxidase, dopamine and Parkinson's disease
Author(s) -
Oreland L.
Publication year - 1991
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1991.tb05021.x
Subject(s) - dopaminergic , monoamine oxidase , dopamine , monoamine oxidase b , parkinson's disease , pathophysiology , selegiline , oxidative deamination , monoamine oxidase a , monoamine neurotransmitter , disease , medicine , neuroscience , chemistry , psychology , enzyme , biochemistry , serotonin , receptor
Four aspects about monoamine oxidase (MAO; E.C. 1.4.3.4) are of obvious interest in relation to Parkinson's disease and its treatment with the irreversible and selective MAO‐B inhibitor L‐deprenyl and are discussed in this review: 1) To what extent the two forms of MAO are of importance for the deamination of dopamine and to what degree MAO localised inside and outside of dopaminergic nerve terminals contributes 2) The kinetics of the MAO‐protein, i.e. the rate of recovery of MAO after irreversible inhibition. 3) To what extent MAO may be changed as a consequence of the pathophysiological processes. 4) To what extent MAO may be involved as a force in the pathophysiological processes.