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Subclinical damage to the nigrostriatal dopamine system by MPTP as a model of preclinical Parkinson's disease: A review
Author(s) -
Burns R. S.
Publication year - 1991
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1991.tb05017.x
Subject(s) - mptp , subclinical infection , parkinson's disease , asymptomatic , dopamine , neuroscience , disease , medicine , cognition , motor function , psychology , degenerative disease , central nervous system disease , physical medicine and rehabilitation
The study of subtle changes in motor and cognitive function after exposure to MPTP might serve as a guide to the very earliest stages of Parkinson's disease. Studies in nonhuman primates and man exposed to MPTP who remained asymptomatic or recovered completely are reviewed. The question of the relationship between the degree and extent of damage to the nigrostriatal dopamine system and changes in motor and cognitive (behavioral) function is addressed. What guidance they provide in the study of subclinical or preclinical Parkinson's disease is discussed.