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TGF‐ β ‐like activity produced during regression of exacerbations in multiple sclerosis
Author(s) -
Beck J.,
Rondot P.,
Jullien P.,
Wietzerbin J.,
Lawrence D. A.
Publication year - 1991
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1991.tb04988.x
Subject(s) - multiple sclerosis , regression , regression analysis , medicine , neuroscience , psychology , immunology , statistics , mathematics , psychotherapist
Samples representative of different stages of disease from a longitudinal study of multiple sclerosis patients were tested in the anchorage‐independent growth assay for TGF‐β and an increased activity was detected in the supernatants from 2‐day blood cell cultures from patients with active disease compared to patients without active disease and healthy donors. Within the group of patients with active disease, the TGF‐β like activity was significantly increased in the subgroup of patients tested during the period of regression of the symptoms where it appeared in 86.9% of the samples. These results suggest that TGF‐β or a TGF‐β like factor may play a role in regeneration processes in multiple sclerosis.