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Does orthotopic liver transplantation heal Wilson's disease? Clinical follow‐up of two liver‐transplanted patients
Author(s) -
Hefter H.,
Rautenberg W.,
Kreuzpaintner G.,
Arendt G.,
Freund H.J.,
Pichlmayr R.,
Strohmeyer G.
Publication year - 1991
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1991.tb04936.x
Subject(s) - medicine , wilson's disease , liver transplantation , transplantation , orthotopic liver transplantation , copper metabolism , surgery , disease , liver disease , liver failure , gastroenterology , chemistry , organic chemistry , copper
Two patients with Wilson's disease (WD) underwent orthotopic liver transplantation, one for subacute liver failure and the other for severe oesophageal haemorrhage. After transplantation both patients fully recovered within five months, and copper metabolism returned to normal. Follow‐up examinations were continued for 4 and 6 years. Clinical as well as electrophysiological testing in these two patients yielded better results than in most of 12 WD‐patients being conventionally treated for a similar period or even longer.