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Natural killer cells and lymphocyte subsets in active MS and acute inflammation of the CNS
Author(s) -
Merelli E.,
Sola P.,
Faglioni P.,
Giordani S.,
Mussini D.,
Montagnani G.
Publication year - 1991
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1991.tb04920.x
Subject(s) - cd3 , multiple sclerosis , cerebrospinal fluid , cd8 , cd16 , monoclonal antibody , immunology , flow cytometry , central nervous system , lymphocyte , medicine , antibody , immune system , pathology
Cerebrospinal fluid (CSF) and peripheral blood (PB) lymphocyte subsets were determined by flow cytometry (FCM) in 15 patients with active multiple sclerosis (MS) and 15 patients with acute inflammatory diseases (ID) of the central nervous system (CNS) in order to establish correlations between the two groups of diseases, as well as between the CSF and PB subsets distribution. A panel of monoclonal antibodies was applied to all the samples: Leu3 (CD4), Leu4 (CD3). Leu2 (CD8), Anti‐HLA‐DR, Leu11 (CD16). Statistical analysis did not show differences in CD3 + nor in CD3 + DR + T‐cells both in the CSF and PB in the two groups of patients. CD4 + cells were significantly higher in the CSF than in the PB, while CD8 +, DR + CD3 ‐ and CD 16 + cells were constantly lower in the CSF without differences between the two groups of diseases.