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Analysis of suppressor activity in experimental allergic encephalomyelitis inhibited by graft‐versus‐host reaction
Author(s) -
Staykova M.,
Kozovska M.,
Nikolova E.,
Goranov I.
Publication year - 1991
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1991.tb04652.x
Subject(s) - encephalomyelitis , immunology , myelin basic protein , cyclophosphamide , antibody , guinea pig , myelin , medicine , in vitro , chemistry , multiple sclerosis , central nervous system , chemotherapy , biochemistry
The induction of local graft‐versus‐host reaction (GvH) prior to the encephalitogenic challenge resulted in the conversion of acute experimental allergic encephalomyelitis (EAE) to the chronic‐like EAE. This inhibitory effect of GvH on EAE development was cyclophosphamide (CY) sensitive. Cell‐free supernatants of peripheral blood lymphocytes (PBL) isolated from guinea pigs with chronic‐like EAE and during recovery from EAE showed suppressor activity on the in vitro proliferative response of myelin basic protein (MBP) sensitized PBL. The appearance of anaphylactic anti‐MBP antibodies and a change in the ratio complement fixing: haemagglutinating (CF/HA) antibodies was also registered.