Premium
Prostacyclin attenuates in the rabbit hippocampus early consequences of transient complete cerebral ischemia
Author(s) -
Pluta R.,
Salinska E.,
Lazarewicz J. W.
Publication year - 1991
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1991.tb03966.x
Subject(s) - prostacyclin , ischemia , hippocampus , transient (computer programming) , rabbit (cipher) , medicine , anesthesia , neuroscience , endocrinology , psychology , statistics , mathematics , computer science , operating system
The effects of prostacyclin (PGI 2 ) on ischemic changes of extracellular calcium concentration (Ca E + 2 ) and the blood‐brain barrier (BBB) permeability were studied by microdialysis of the rabbit hippocampus. This was combined with morphological and neurophysiological observations. Complete cerebral ischemia lasting 15 min was produced by ligation of the brachiocephalic trunk, the left subclavian and both internal thoracic arteries. PGI 2 was infused continuously i.v. in the last 3 min of ischemia and for 40 min after it, at a rate of 2 μg/kg/min. Control rabbits were submitted to untreated 15‐min complete cerebral ischemia. The animals treated with PGI 2 were found to have recovered bioelectric activity of the cortex and hippocampus in half the time that it took the untreated group. Application of PGI 2 reduced by 60% the depth of ischemia‐evoked drop of the Ca E + 2 without acceleration of recovery during recirculation. The postischemic increase of BBB permeability to fluorescein was diminished. The number of morphologically changed neurons in the hippocampus of PGI 2 ‐treated animals was significantly lower than in the untreated group.