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Disturbed hypothalamic‐pituitary axis in idiopathic recurring hypersomnia syndrome
Author(s) -
Fernábdez J.M.,
Lara I.,
Gila L.,
O'Neill A.,
Tovar J.,
Gimeno A.
Publication year - 1990
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1990.tb03317.x
Subject(s) - endocrinology , medicine , hypoglycemia , hypothalamic disease , hypothalamic–pituitary–thyroid axis , hypothalamic–pituitary–adrenal axis , thyroid , insulin , hormone , thyroid hormones , hypogonadotropic hypogonadism
Disturbed function of the hypothalamic‐pituitary axis at adrenal and thyroid levels was found during an episode of hypersomnia in the idiopathic recurring hypersomnia syndrome. These endocrinological abnormalities, abolished ACTH and cortisol responses to insulin‐induced hypoglycemia and absent TSH response to TRH, normalised thereafter in the symptom‐free interval. These data support the hypothesis that Kleine‐Levin syndrome is related to an intermittent hypothalamic dysfunction.