Premium
Plasma exchange in Guillain‐Barré syndrome: effect on anti‐peripheral nerve myelin antibodies
Author(s) -
Vedeler C. A.,
Nyland H.
Publication year - 1990
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1990.tb01606.x
Subject(s) - guillain barre syndrome , antibody , medicine , myelin , peripheral , peripheral nerve , peripheral neuropathy , immunology , myelin sheath , pathology , gastroenterology , endocrinology , central nervous system , anatomy , diabetes mellitus
Increased levels of anti‐peripheral nerve myelin (anti‐PNM) antibodies were demonstrated by ELISA in serum from 4 of 7 patients with Guillain‐Barré syndrome (GBS). Treatment with plasma exchange (PE) was performed and 6 of the 7 patients showed clinical improvement with marked increase in muscular strength. One patient, however, continued to deteriorate during the treatment. No correlation between clinical improvement and levels of anti‐PNM antibodies was observed. Whether the antibodies are of pathogenetic importance in GBS is therefore still unknown.