Premium
Lone atrial fibrillation and stroke
Author(s) -
Bogousslavsky J.,
AdnetBonte C.,
Regli F.,
Melle G.,
Kappenberger L.
Publication year - 1990
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1990.tb01605.x
Subject(s) - medicine , atrial fibrillation , stroke (engine) , cardiology , thrombus , anticoagulant therapy , anticoagulant , mechanical engineering , engineering
We studied 21 consecutive patients from the Lausanne Stroke Registry, who had first‐ever ischemic stroke and lone atrial fibrillation, with a standard protocol of investigations including brain CT, and non‐invasive cardiac and arterial tests. Rarity of associated risk factors and extracranial; arterial disease, presence of distal intracerebral occlusions on early angiography, and topography of cerebral infarct suggested that cardioembolism was the cause of stroke, though echocardiographic evidence for an atrial thrombus was uncommon. There was no recurrence during a post‐stoke 14‐day phase, during which anticoagulant and antiaggregant therapies were systematically avoided. Though low, the main risk of stroke recurrence was 0.99 per 100 patient‐years during a mean follow‐up period of 4.8 years, including a mean duration of anticoagulant therapy of 2.3 years in 18 patients. On the other hand, no death, severe cardiac events, or disabling anticoagulation‐related hemorrhages occurred.