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Increased intrathecal synthesis of fibronectin in bacterial and carcinomatous meningitis
Author(s) -
Weller M.,
Sommer N.,
Stevens A.,
Wiethölter H.
Publication year - 1990
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1990.tb01604.x
Subject(s) - cerebrospinal fluid , meningitis , bacterial meningitis , encephalitis , fibronectin , medicine , intrathecal , csf albumin , pathology , immunology , multiple sclerosis , gastroenterology , biology , virus , anesthesia , surgery , extracellular matrix , microbiology and biotechnology
Immunoreactive fibronectin (Fn) was quantified in paired cerebrospinal fluid (CSF) and serum samples from patients with bacterial meningitis (n = 46), tick‐borne encephalitis (TBE) (n = 6), HIV infection (n = 6), Guillain‐Barré syndrome (n = 5), carcinomatous meningitis (n = 11), multiple sclerosis (n = 15), disk disease (n = 11), and controls (n = 28). A highly significant elevation of CSF Fn was found in bacterial meningitis, TBE, and carcinomatous meningitis. There were no significant differences in serum Fn between any of the groups. An Fn index to estimate the rate of intrathecal Fn synthesis reached the highest value in bacterial meningitis. Our findings suggest that CSF Fn may be an indicator of adequate host reaction and tissue repair. For diagnostic purposes, the determination of CSF Fn probably does not add much to routine CSF laboratory tests.