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Subclinical lithium neurotoxicity: correlation of neural conduction abnormalities and serum lithium level in manic‐depressive patients with lithium treatment
Author(s) -
Chang Y.C.,
Lin H.N.,
Deng H.C.
Publication year - 1990
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1990.tb01593.x
Subject(s) - lithium (medication) , subclinical infection , neurotoxicity , medicine , anesthesia , somatosensory evoked potential , bipolar disorder , audiology , psychology , toxicity
Nerve conduction velocities (NCVs) and multimodality evoked potentials were studies in 28 manic‐depressive patients under lithium prophylaxis with serum lithium levels between 0.320 and 0.980 mEq/L. Slowing of motor and sensory NCVs and prolonged central neural conduction times obtained from somatosensory and brainstem auditory evoked potentials were found to correlate with serum lithium levels. Lithium‐induced changes in cell membrane conductivity and in the synaptic transmission are considered responsible for the neurotoxic effects of lithium.