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Specific in vitro IgG subclass synthesis and lymphocyte proliferation responses in herpes virus encephalitis
Author(s) -
Mathiesen T.,
OldingStenkvist E.,
Linde A.,
Olsson O.,
Wahren B.
Publication year - 1990
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1990.tb01567.x
Subject(s) - encephalitis , immunology , meningoencephalitis , virology , herpes simplex virus , subclass , in vitro , virus , heterologous , biology , varicella zoster virus , simplexvirus , herpesviridae , antibody , viral disease , biochemistry , gene
Cerebrospinal fluid, peripheral blood lymphocytes (PBL) and sera from 5 patients with herpes simplex encephalitis (HSVE), 3 with varicellae zoster (VZV) meningoencephalitis and 5 with encephalitis of unknown origin (NUD) were analyzed. Lymphocytes from both blood and CSF were shown to synthesize anti‐VZV IgG subclasses in VZV meningoencephalitis and anti‐HSV IgG subclasses in HSVE. The subclass patterns of CSF and in vitro synthesized anti‐viral IgG were similar, suggesting that a considerable portion of the antiviral IgG subclasses detected are synthesized in the CNS compartment. Antigen presentation in vitro seemed to produce a heterologous IgG4 and/or 3 response in 3 patients. Lymphocyte proliferation was detectable in response to HSV and VZV, respectively.