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Blood brain barrier function in vascular dementia
Author(s) -
Wallin A.,
Blennow K.,
Fredman P.,
Gottfries C. G.,
Karlsson I.,
Svennerholm L.
Publication year - 1990
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1990.tb01562.x
Subject(s) - blood–brain barrier , dementia , vascular dementia , albumin , cerebrospinal fluid , medicine , serum albumin , brain function , pathology , endocrinology , central nervous system , psychology , neuroscience , disease
To investigate blood‐brain barrier (BBB) function measured as an albumin ratio (cerebrospinal fluid/serum) in vascular dementia (VD) samples from 53 patients and 30 healthy controls were analysed. The VD group showed a higher mean albumin ratio than controls (8.5 ± 3.8 and 5.7 ± 2.1, respectively). The albumin ratio did not correlate significantly with age, nor with individual clinical vascular factors. The results of the present study suggest that the altered BBB might be a consequence of small vessel disorder rather than evidence of infarcts.